Year: 2024 | Month: July-September | Volume: 9 | Issue: 3 | Pages: 205-216
DOI: https://doi.org/10.52403/ijshr.20240324
Genetic Diversity of Plasmodium falciparum in Northern Taraba State, Nigeria
Obiorah C.S1, Elkanah O.S2, Kela S.L3, Barka J.S4, Christopher P.N5, Onyeuku O.C6
1Department of Medical Laboratory Services, Federal Medical Center, Jalingo, Taraba State, Nigeria.
2Department of Biological Sciences, Taraba State University, Jalingo, Taraba State, Nigeria.
3Department of Biological Sciences, Federal University, Kashere, Gombe State, Nigeria.
4Department of Biological Sciences, Gombe State University, Gombe State, Nigeria.
5Department of Public Health, Federal Medical Center Jalingo, Taraba State, Nigeria.
6Department of Medical Laboratory Services, Taraba State Specialist Hospital, Jalingo, Taraba State, Nigeria.
Corresponding Author: Obiorah C.S
ABSTRACT
Background: Osteoarthritis (OA); a whole joint disorder is a most common and progressive disease that worsens with age. Synovitis and synovial effusion can play important role in early OA diagnosis and progression. Limited pharmacological interventions affecting synovial effusion are studied clinically in Indian population.
Aim: This was a pilot, observational, single arm, open label study in real world set-up designed to evaluate the efficacy and safety of Mobileye® capsules containing sodium hyaluronate along with collagen and polysaccharides derived from rooster comb extract in subjects suffering from synovial effusion and knee pain of osteoarthritis.
Materials and Method: The study was conducted on total 30 subjects at Outpatient Department (OPD) at three different sites under the supervision of medical doctor. All subjects consumed Mobileye® capsule orally twice daily for 3 months. Synovial effusion, VAS score, WOMAC score and safety parameters were assessed as scheduled.
Results: Treatment with Mobileye® capsule showed significant and progressive improvement in all study related parameters. Baseline score vs. day 90 score (mean + SD) for synovial effusion, WOMAC pain score, WOMAC stiffness score, WOMAC physical function score, WOMAC total score and VAS score were 8.52+2.960 mm vs. 2.58+0.903 mm (p<0.0001), 15.13+3.10 vs. 4.13+2.4 (p<0.0001), 6.63+1.098 vs. 1.60+1.192 (p<0.0001), 54.33+8.39 vs. 14.23+8.67 (p<0.0001), 76.13+ 11 vs. 20.33+ 10.86 and 8.13 + 1.28 vs. 1.93+1.17 (p<0.0001) respectively. No significant adverse events were reported.
Conclusion: Oral intake of Mobileye® capsule is safe and effective intervention in reducing synovial effusion, pain, stiffness and in improving joint mobility.
Keywords: Malaria, Plasmodium falciparum, genetic, merozoites surface proteins.